Antibiotic prophylaxis for children with recurrent respiratory infections: towards evidence-based guidelines

The Approach trial is a multicenter randomized controlled trial comparing the efficacy of prophylactic co-trimoxazol with placebo in children aged 6 months to 10 years with recurrent respiratory infections.  In addition, samples are taken from participating children to look at the functioning of the immune system, both in the blood and on the mucous membranes.

Participating centers: Juliana Kinderziekenhuis, Radboudumc, Wilhelmina Kinderziekenhuis, Spaarne Gasthuis, Isala, Amsterdam UMC, Reinier de Graaf gasthuis, Groene Hart Ziekenhuis, St. Antonius ziekenhuis, Haaglanden Medisch Centrum, Franciscus Gasthuis, Elisabeth-Tweestedenziekenhuis, Jeroen Bosch Ziekenhuis, Bernhoven, Zuyderland Medisch Centrum

For more information visit: Approach study